Thermoregulation, Stress, and the Physiological Benefits of Sauna Use

Thermoregulation, Stress, and the Physiological Benefits of Sauna Use

Saunas are a tool. They can support longevity, improve quality of life, and enhance overall performance and recovery. But they are not a one dimensional solution. Because they influence multiple systems in the body, the way you use a sauna should depend on the outcome you’re trying to achieve.

We’ve read and consumed research across traditional literature, contemporary studies, and the work of leading scientists in the field. The protocols and supporting research are linked throughout this paper, with a full works cited section below.

This paper outlines how saunas work, the physiological processes they initiate, the protocols aligned with specific goals, and what actually holds up under scrutiny versus what does not. The objective is clarity: to help you use the sauna with intention and measurable results.

Basic Thermoregulation

The body regulates temperature through two distinct but interconnected zones: shell temperature and core temperature.

Shell temperature refers to the temperature of the skin and superficial tissues. It changes rapidly in response to the environment. Wind, humidity, water exposure, or air temperature can shift shell temperature within seconds.

Core temperature refers to the temperature of internal organs and deep tissues. Core temperature is tightly controlled because even small deviations can impair cellular function.

The primary control center for temperature regulation is the preoptic area (POA) of the hypothalamus. The POA continuously receives input from:

  • Peripheral thermoreceptors in the skin (monitoring shell temperature)
  • Central thermoreceptors in the spinal cord and brain (monitoring core temperature)

It integrates these signals and initiates appropriate responses to maintain stability.

When the skin detects heat, peripheral receptors send signals to the POA. The brain interprets this as a potential thermal threat and activates regulation.

Temperature change in the body is gradient-driven, meaning the environment influences the shell first, then the shell influences the core. Core temperature does not immediately rise simply because the surrounding air or water is hot. The body initially attempts to defend core stability.

This leads to a counterintuitive principle: heating is regulated through cooling. When the surface of the body warms, blood is redistributed from deeper tissues toward the skin. Sweating begins. These mechanisms are designed to dissipate heat and protect internal organs. Early in thermal exposure, core temperature may remain stable or shift minimally because cooling systems are fully active.

Only when external heat load exceeds the body’s ability to dissipate it does core temperature begin to rise in a sustained way. At that point, deeper physiological adaptations are triggered. The shell acts as the sensor and interface with the environment. The core is the protected center. The brain, through the POA, coordinates the exchange between the two.

What processes do thermoregulation activate?

Thermoregulation activates multiple bodily processes. In this paper we will explain the few important ones that create the desired outcomes of sauna use.

The first being the cooling processes

When the thermoreceptors in the skin and shell detect heat, the signal is transmitted to the hypothalamus, which starts the immediate cooling process. The physiological response is to:

  • Increase plasma volume: improving the ability to circulate blood.
  • Increase peripheral blood flow: allowing more internal heat to be transported from the core to the surface.
  • Increase stroke volume: meaning the heart pumps more blood per beat, increasing the amount of warm blood delivered to the skin with each contraction.
  • Increase heart rate: more beats per minute.
  • Vasodilation: widening of blood vessels, particularly near the surface of the skin, which increases blood flow to peripheral tissues.
  • Sweating: sweating cools by the release of fluid onto the skin’s surface. As this fluid evaporates, it removes heat from the body, lowering temperature.

The second is the release of Heat Shock Proteins, or sometimes known as (HSPs)

The basic understanding of HSPs is that they preserve a process called proteostasis. This means they assist and facilitate protein synthesis, folding, and degradation (the process of breaking down proteins into smaller peptides or amino acids).

Proteostasis is essential for these functions:

  • Quality control. Misfolded or damaged proteins are eliminated before they grow/combine and disrupt cellular function.
  • Regulation. Many proteins are degraded deliberately to control signaling pathways and timing of biological processes.
  • Resource recycling. Amino acids released from degraded proteins are reused for new protein synthesis or metabolic pathways.

They are deployed in humans through a change in environment. This can be through a stress derived from heat, cold, UV, osmotic stress, or pH shifts.

Without HSPs, cells would accumulate misfolded and damaged proteins, leading to impaired cellular function, increased inflammation, and accelerated degeneration. Over time, this would reduce tissue resilience and compromise recovery capacity.

HSP activation includes:

  • Enhanced cellular resilience
  • Improved recovery from physical or environmental stress
  • Contributions to longevity

The third is the release of Dynorphins

These are the opposite of endorphins. They upregulate during a stress response to make you feel worse, the panic you feel during a hard sauna session. They are there to get the body out of stressful situations.

They:

  • Increase discomfort
  • Increase alertness
  • Increase focus
  • Create a mild stress signal

However, downstream of dynorphin release is the increase in other receptors that bind to dopamine and endorphins. The pleasure pain balance in the body is skewed, so there is a natural production and release of endorphins, as well as an increased number of receptor sites.

Thus, dynorphins increase our baseline level of mood, and allow “good” events to be perceived as “great” ones.

Short-term dynorphin stress makes the dopamine system more responsive afterward:

  • Improves stress tolerance
  • Increases mental resilience
  • Stabilizes mood response
  • Reduces baseline inflammation

It’s not how saunas create heat that makes them so beneficial. It’s that they are the most efficient way to receive the heat necessary to make real effective change. In the studies that measured these processes in action and at maximum effectiveness, it was a range of 176 - 212 degrees fahrenheit that sparked these processes. If you think you need infrared, look at the basic scientific principles that make saunas effective and ask yourself, am I consistently hitting that heat range? If not, you are just getting warm.

Sauna use is effective because it forces the body to regulate heat through a coordinated stress response. The shell detects environmental heat first, the hypothalamus responds by activating cooling mechanisms, and the body works to protect core temperature through increased circulation, sweating, vasodilation, and cardiovascular output. When the heat load is strong enough, deeper adaptations occur, including heat shock protein activation and dynorphin-driven stress signaling. These processes support cellular repair, recovery, resilience, mood regulation, and improved tolerance to physical and environmental stress. The benefit of sauna use is not simply feeling warm; it comes from reaching a high enough thermal stimulus to activate the body’s full thermoregulatory and adaptive systems.

- Western Sol

The Sauna Facts

The Sauna Facts

(Using a sauna 4–7 times per week, unless noted otherwise)

  • 40% lower all-cause mortalityFrequent sauna use was associated with a multivariable-adjusted hazard ratio of 0.60 for all-cause mortality compared with once-weekly sauna use. Laukkanen et al., 2015.
  • 63% lower risk of sudden cardiac death4–7 sauna sessions per week were associated with a hazard ratio of 0.37 for sudden cardiac death compared with once weekly. Laukkanen et al., 2015.
  • 48% lower fatal coronary heart disease risk4–7 sessions weekly were associated with a hazard ratio of 0.52 for fatal coronary heart disease. Laukkanen et al., 2015.
  • 50% lower fatal cardiovascular disease risk4–7 sessions weekly were associated with a hazard ratio of 0.50 for fatal cardiovascular disease. Laukkanen et al., 2015.
  • 64% lower cardiovascular mortality in men and womenIn a later prospective cohort including both men and women, 4–7 sessions weekly were associated with a multivariable-adjusted hazard ratio of 0.36 for cardiovascular mortality. Laukkanen et al., 2018.
  • Dose-response cardiovascular protectionCardiovascular mortality decreased as sauna frequency increased from one to seven sessions per week. Laukkanen et al., 2018.
  • Lower cardiovascular mortality rateCardiovascular mortality rates were 10.1 per 1,000 person-years for once-weekly sauna users versus 2.7 per 1,000 person-years for 4–7 times weekly users. Laukkanen et al., 2018.
  • 47% lower risk of developing hypertension4–7 sauna sessions weekly were associated with a fully adjusted hazard ratio of 0.53 for incident hypertension. Zaccardi et al., 2017.
  • Immediate blood pressure reduction after saunaA 30-minute sauna session reduced mean systolic blood pressure from 137 to 130 mmHg and diastolic blood pressure from 82 to 75 mmHg. Laukkanen et al., 2018.
  • Lower blood pressure remained after recoverySystolic blood pressure was still lower 30 minutes after sauna exposure compared with pre-sauna levels. Laukkanen et al., 2018.
  • Improved cardiovascular function markersSauna exposure acutely changed arterial stiffness, blood pressure, and blood-based cardiovascular markers in participants with at least one cardiovascular risk factor. Laukkanen et al., 2018.
  • Potential exercise-like cardiovascular stimulusSauna bathing increases cardiovascular strain through heat-driven circulation changes, which is one reason researchers compare portions of the response to light or moderate exercise. Laukkanen et al., 2018.
  • Reduced systemic inflammation marker4–7 sauna sessions weekly were associated with lower high-sensitivity C-reactive protein compared with once-weekly use. Kunutsor, Laukkanen & Laukkanen, 2018.
  • Lower hsCRP specifically: 1.65 vs. 2.41 mg/LMen using sauna 4–7 times weekly had mean CRP of 1.65 mg/L versus 2.41 mg/L in once-weekly users, roughly 32% lower, not 68%, based on this source. Laukkanen & Laukkanen, 2018.
  • Lower leukocyte countFrequent sauna bathing was associated with lower white blood cell count at baseline and at 11-year follow-up, suggesting reduced inflammatory burden. Kunutsor, Laukkanen & Laukkanen, 2018.
  • Lower fibrinogen over time4–7 weekly sauna sessions were associated with lower fibrinogen at 11-year follow-up. Kunutsor, Laukkanen & Laukkanen, 2018.
  • 66% lower dementia risk4–7 sauna sessions weekly were associated with a hazard ratio of 0.34 for dementia compared with once-weekly sauna use. Laukkanen et al., 2017.
  • Reduced Alzheimer’s disease riskThe same Finnish cohort found sauna bathing was inversely associated with Alzheimer’s disease risk in middle-aged Finnish men. Laukkanen et al., 2017.
  • Potential pneumonia risk reductionFrequent sauna bathing was associated with reduced pneumonia risk in middle-aged Caucasian men. Kunutsor, Laukkanen & Laukkanen, 2017.
  • Respiratory function supportSauna bathing may improve lung function and breathing measures, including forced expiratory volume and vital capacity, though the respiratory evidence base is smaller than the cardiovascular evidence base. Laukkanen et al., 2018 review.
  • Better epidermal barrier functionRegular sauna use was associated with more stable epidermal barrier function in a controlled human skin physiology study. Kowatzki et al., 2008.
  • Improved stratum corneum water-holding capacityRegular sauna bathing improved skin water-holding capacity, a marker of skin barrier quality. Kowatzki et al., 2008.
  • Reduced oily skin marker on the foreheadRegular sauna use decreased casual skin sebum content on the forehead. Kowatzki et al., 2008.
  • Protective effect on skin physiologyRegular sauna bathing showed beneficial effects on skin barrier function and surface physiology. Kowatzki et al., 2008.
  • Growth hormone response under high heat stressRepeated Finnish sauna exposure at 80°C affected growth hormone and prolactin secretion in healthy men and women. Leppäluoto et al., 1986.
  • Endocrine stress adaptationSauna exposure influences several hormonal systems, including noradrenaline, antidiuretic hormone, and the renin-angiotensin-aldosterone system. Kukkonen-Harjula & Kauppinen, 1988.
  • Improved endothelial function through passive heat therapyRepeated heat therapy improved flow-mediated dilation, a marker of endothelial function, in sedentary humans. Brunt et al., 2016.
  • Reduced arterial stiffness through passive heat therapyEight weeks of heat therapy reduced aortic pulse wave velocity, a marker of arterial stiffness. Brunt et al., 2016.
  • Lower mean arterial pressure after heat therapyEight weeks of heat therapy reduced mean arterial pressure from 83 to 78 mmHg in sedentary humans. Brunt et al., 2016.
  • Synergy with cardiorespiratory fitnessSauna bathing combined with higher cardiorespiratory fitness was associated with lower cardiovascular and all-cause mortality risk than either factor alone. Kunutsor et al., 2018.
  • Longer sessions may matterSessions lasting more than 19 minutes were associated with lower sudden cardiac death, fatal coronary heart disease, and fatal cardiovascular disease risk compared with sessions under 11 minutes. Laukkanen et al., 2015.
  • More total weekly sauna time may matterMore than 45 minutes per week was associated with lower cardiovascular mortality than 15 minutes or less per week. Laukkanen et al., 2018.
  • Traditional sauna heat range mattersThe major Finnish cardiovascular studies involved traditional sauna bathing around 75–80°C, roughly 167–176°F, with many protocols occurring in the 176°F range or higher. Laukkanen et al., 2015; Laukkanen et al., 2018.
  • Best-supported use case: cardiovascular healthAcross the sauna literature, the strongest evidence is for cardiovascular associations: lower blood pressure, lower cardiovascular mortality, lower sudden cardiac death risk, and improved vascular function. Laukkanen et al., 2018 review.

Keys to an Optimal Sauna Session

  1. Use timing to influence the sleep/wake cycle. Morning or early-day sauna sessions are best when the goal is alertness, focus, and wakefulness. Evening sauna sessions are best when the goal is relaxation and sleep support.
  2. For wakefulness, use the sauna earlier in the day and end with a cold plunge. A morning session can raise heart rate, circulation, body temperature, and alertness. This can help reinforce the body’s natural daytime activation rhythm. Ending with cold increases the body’s core temp - to assist with your sleep/wake cycle.
  3. For sleep, use the sauna 1–3 hours before bed. Sauna use raises body temperature during the session. After exiting, the body cools down, which may support the natural drop in core temperature associated with sleep onset.
  4. Avoid intense sauna sessions immediately before bed. If heart rate remains elevated, the nervous system may stay activated too close to sleep. For nighttime use, prioritize a controlled session followed by a calm cooldown.
  5. Hydrate before entering. Drink approximately 16–32 oz of water in the 60–90 minutes before sauna use. Include electrolytes, especially sodium, if the session will be long, hot, or paired with exercise.
  6. Do not rely on water alone during heavy sweating. Sauna use causes loss of water and minerals through sweat. Sodium, potassium, magnesium, and chloride help maintain fluid balance, circulation, and heat tolerance.
  7. Rehydrate immediately after the session. Replace fluid lost through sweat after leaving the sauna. A practical target is 16–32 oz of water with electrolytes after a standard session, with more needed after long or repeated rounds.
  8. Eat far enough away from the session. Avoid entering the sauna immediately after a heavy meal. Digestion already increases blood flow to the gut, while sauna use redirects blood toward the skin for cooling.
  9. Use a 1.5–3 hour gap after large meals. This reduces nausea, sluggishness, and cardiovascular strain during heat exposure.
  10. Use light food if needed before sauna. If training, fasting, or low energy makes sauna use uncomfortable, a small snack such as fruit, yogurt, or a light protein source can be used 30–60 minutes before the session.
  11. Avoid alcohol before sauna use. Alcohol increases dehydration risk, impairs temperature regulation, and adds unnecessary cardiovascular strain.
  12. Match cooldown to the goal. Passive cooling supports relaxation and sleep. Cold exposure after sauna may increase alertness and perceived recovery, making it better suited for daytime use.
  13. Control breathing during the session. Slow nasal breathing helps regulate discomfort and prevent panic-driven overbreathing. Heat tolerance improves when breathing remains controlled.
  14. Exit when the stress signal becomes excessive. Dizziness, confusion, chest pain, severe nausea, or visual changes indicate the session has moved beyond productive stress.

Sauna Protocols

General Physical Wellbeing Protocol:

  • Temperature: 176–212°F
  • Duration: 15–25 minutes
  • Frequency: 4–6 sessions per week
  • Hydration: Aggressive electrolyte and water intake before and after use
  • Cooldown: Optional cold rinse or ambient cooldown after session

Supporting Research & Sources

Growth Hormone Release Protocol:

  • Temperature: 185–212°F
  • Protocol Structure:
    • 30 minutes sauna
    • 5–10 minute break
    • Repeat for 2–4 total rounds
    • 30 mins on, 5 off - repeat 3-4x
  • Frequency: Once every 10 days or less
  • Hydration: Mandatory
  • Avoid heavy meals 2–3 hours before session

Supporting Research & Sources

Mental Health & Focus Protocol

  • Temperature: 176–194°F
  • Duration: 15–20 minutes
  • Frequency: 3–5 times weekly
  • Optional: Contrast with cold exposure after sauna for natural endorphin release
  • Best timing: Morning or early afternoon

Supporting Research & Sources

Disclaimer

These protocols are educational and informational only and are not medical advice. Individuals with cardiovascular disease, blood pressure disorders, pregnancy, heat intolerance, or other medical conditions should consult a physician before engaging in deliberate heat exposure.

Works Cited

Brunt, V. E., Howard, M. J., Francisco, M. A., Ely, B. R., & Minson, C. T. (2016). Passive heat therapy improves endothelial function, arterial stiffness and blood pressure in sedentary humans. The Journal of Physiology, 594(18), 5329–5342. https://doi.org/10.1113/JP272453

Huberman, A. (2022, April 25). The science & health benefits of deliberate heat exposure. Huberman Lab. https://www.hubermanlab.com/episode/the-science-and-health-benefits-of-deliberate-heat-exposure

Huberman, A. (2022). Deliberate heat exposure protocols for health & performance. Huberman Lab. https://www.hubermanlab.com/newsletter/deliberate-heat-exposure-protocols-for-health-and-performance

Huberman, A. (2026, March 12). Essentials: Benefits of sauna & deliberate heat exposure. Huberman Lab. https://www.hubermanlab.com/episode/essentials-benefits-of-sauna-and-deliberate-heat-exposure

Huberman Lab. (n.d.). Sauna and heat exposure. Retrieved May 11, 2026, from https://www.hubermanlab.com/topics/sauna-and-heat-exposure

Jezova, D., Radikova, Z., & Vigas, M. (2007). Growth hormone response to different consecutive stress stimuli in healthy men: Is there any difference? Stress, 10(2), 205–211. https://doi.org/10.1080/10253890701292168

Johnson, B. (2025, July 25). Is sauna worth the hype? [Video]. YouTube. https://www.youtube.com/watch?v=brzapjVGYLk

Johnson, B. (2025, November 7). Is sauna actually good for you? (90-day experiment) [Video]. YouTube. https://www.youtube.com/live/kiUM92VDI1Y

Johnson, B. (2026). Sauna is one of the most effective health protocols I’ve done [Post]. LinkedIn. https://www.linkedin.com/posts/bryanrjohnson_sauna-is-one-of-the-most-effective-health-activity-7404655111576223744-tIrx

Johnson, B. (2026, January 28). My #1 longevity protocol of 2025. Blueprint. https://blueprint.bryanjohnson.com/blogs/news/sauna-protocol

Kivimäki, M., Virtanen, M., & Ferrie, J. E. (2015). The link between sauna bathing and mortality may be noncausal. JAMA Internal Medicine, 175(10), 1718. https://doi.org/10.1001/jamainternmed.2015.3426

Kowatzki, D., Macholdt, C., Krull, K., Schmidt, D., Deufel, T., Elsner, P., & Fluhr, J. W. (2008). Effect of regular sauna on epidermal barrier function and stratum corneum water-holding capacity in vivo in humans: A controlled study. Dermatology, 217(2), 173–180. https://doi.org/10.1159/000137283

Kukkonen-Harjula, K., & Kauppinen, K. (1988). Health effects and risks of sauna bathing. Annals of Clinical Research, 20(4), 262–266.

Kunutsor, S. K., Laukkanen, T., & Laukkanen, J. A. (2017). Frequent sauna bathing may reduce the risk of pneumonia in middle-aged Caucasian men: The KIHD prospective cohort study. Respiratory Medicine, 132, 161–163. https://doi.org/10.1016/j.rmed.2017.10.018

Kunutsor, S. K., Laukkanen, T., & Laukkanen, J. A. (2018). Longitudinal associations of sauna bathing with inflammation and oxidative stress: The KIHD prospective cohort study. Annals of Medicine, 50(5), 437–442. https://doi.org/10.1080/07853890.2018.1489143

Kunutsor, S. K., Khan, H., Laukkanen, T., & Laukkanen, J. A. (2018). Joint associations of sauna bathing and cardiorespiratory fitness on cardiovascular and all-cause mortality risk: A long-term prospective cohort study. Annals of Medicine, 50(2), 139–146. https://doi.org/10.1080/07853890.2017.1387927

Laukkanen, J. A., & Laukkanen, T. (2018). Sauna bathing and systemic inflammation. European Journal of Epidemiology, 33(3), 351–353. https://doi.org/10.1007/s10654-017-0335-y

Laukkanen, J. A., Laukkanen, T., & Kunutsor, S. K. (2018). Cardiovascular and other health benefits of sauna bathing: A review of the evidence. Mayo Clinic Proceedings, 93(8), 1111–1121. https://doi.org/10.1016/j.mayocp.2018.04.008

Laukkanen, T., Khan, H., Zaccardi, F., & Laukkanen, J. A. (2015). Association between sauna bathing and fatal cardiovascular and all-cause mortality events. JAMA Internal Medicine, 175(4), 542–548. https://doi.org/10.1001/jamainternmed.2014.8187

Laukkanen, T., Khan, H., & Zaccardi, F. (2015). The link between sauna bathing and mortality may be noncausal—Reply. JAMA Internal Medicine, 175(10), 1719. https://doi.org/10.1001/jamainternmed.2015.3432

Laukkanen, T., Kunutsor, S. K., Kauhanen, J., & Laukkanen, J. A. (2017). Sauna bathing is inversely associated with dementia and Alzheimer’s disease in middle-aged Finnish men. Age and Ageing, 46(2), 245–249. https://doi.org/10.1093/ageing/afw212

Laukkanen, T., Kunutsor, S. K., Zaccardi, F., Lee, E., Willeit, P., Khan, H., & Laukkanen, J. A. (2018). Acute effects of sauna bathing on cardiovascular function. Journal of Human Hypertension, 32, 129–138. https://doi.org/10.1038/s41371-017-0008-z

Laukkanen, T., Kunutsor, S. K., Khan, H., Willeit, P., Zaccardi, F., & Laukkanen, J. A. (2018). Sauna bathing is associated with reduced cardiovascular mortality and improves risk prediction in men and women: A prospective cohort study. BMC Medicine, 16, Article 219. https://doi.org/10.1186/s12916-018-1198-0

Lee, E., Kolunsarka, I., Kostensalo, J., Ahtiainen, J. P., Haapala, E. A., Willeit, P., Kunutsor, S. K., & Laukkanen, J. A. (2022). Effects of regular sauna bathing in conjunction with exercise on cardiovascular function: A multi-arm, randomized controlled trial. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 323(3), R289–R299. https://doi.org/10.1152/ajpregu.00076.2022

Leppäluoto, J., Huttunen, P., Hirvonen, J., Väänänen, A., Tuominen, M., & Vuori, J. (1986). Endocrine effects of repeated sauna bathing. Acta Physiologica Scandinavica, 128(3), 467–470. https://doi.org/10.1111/j.1748-1716.1986.tb08000.x

Podstawski, R., Borysławski, K., Pomianowski, A., Żurek, P., & Żurek, G. (2021). Endocrine effects of repeated hot thermal stress and cold water immersion in young adult men. American Journal of Men’s Health, 15(2). https://doi.org/10.1177/15579883211008339

Zaccardi, F., Laukkanen, T., Willeit, P., Kunutsor, S. K., Kauhanen, J., & Laukkanen, J. A. (2017). Sauna bathing and incident hypertension: A prospective cohort study. American Journal of Hypertension, 30(11), 1120–1125. https://doi.org/10.1093/ajh/hpx102

was added to your cart.